DESIGN AND EVALUATION OF RESOURCE ALLOCATION AND JOB SCHEDULING ALGORITHMS ON COMPUTATIONAL GRIDS

Grid, an infrastructure for resource sharing, currently has shown its importance in many scientific applications requiring tremendously high computational power. Grid computing enables sharing, selection and aggregation of resources for solving complex and large-scale scientific problems. Grids computing, whose resources are distributed, heterogeneous and dynamic in nature, introduces a number of fascinating issues in resource management. Grid scheduling is the key issue in grid environment in which its system must meet the functional requirements of heterogeneous domains, which are sometimes conflicting in nature also, like user, application, and network. Moreover, the system must satisfy non-functional requirements like reliability, efficiency, performance, effective resource utilization, and scalability. Thus, overall aim of this research is to introduce new grid scheduling algorithms for resource allocation as well as for job scheduling for enabling a highly efficient and effective utilization of the resources in executing various applications. The four prime aspects of this work are: firstly, a model of the grid scheduling problem for dynamic grid computing environment; secondly, development of a new web based simulator (SyedWSim), enabling the grid users to conduct a statistical analysis of grid workload traces and provides a realistic basis for experimentation in resource allocation and job scheduling algorithms on a grid; thirdly, proposal of a new grid resource allocation method of optimal computational cost using synthetic and real workload traces with respect to other allocation methods; and finally, proposal of some new job scheduling algorithms of optimal performance considering parameters like waiting time, turnaround time, response time, bounded slowdown, completion time and stretch time. The issue is not only to develop new algorithms, but also to evaluate them on an experimental computational grid, using synthetic and real workload traces, along with the other existing job scheduling algorithms. Experimental evaluation confirmed that the proposed grid scheduling algorithms possess a high degree of optimality in performance, efficiency and scalability

DESIGN AND EVALUATION OF RESOURCE ALLOCATION AND JOB SCHEDULING ALGORITHMS ON COMPUTATIONAL GRIDS

Grid, an infrastructure for resource sharing, currently has shown its importance in many scientific applications requiring tremendously high computational power. Grid computing enables sharing, selection and aggregation of resources for solving complex and large-scale scientific problems. Grids computing, whose resources are distributed, heterogeneous and dynamic in nature, introduces a number of fascinating issues in resource management. Grid scheduling is the key issue in grid environment in which its system must meet the functional requirements of heterogeneous domains, which are sometimes conflicting in nature also, like user, application, and network. Moreover, the system must satisfy non-functional requirements like reliability, efficiency, performance, effective resource utilization, and scalability. Thus, overall aim of this research is to introduce new grid scheduling algorithms for resource allocation as well as for job scheduling for enabling a highly efficient and effective utilization of the resources in executing various applications. The four prime aspects of this work are: firstly, a model of the grid scheduling problem for dynamic grid computing environment; secondly, development of a new web based simulator (SyedWSim), enabling the grid users to conduct a statistical\ud analysis of grid workload traces and provides a realistic basis for experimentation in resource allocation and job scheduling algorithms on a grid; thirdly, proposal of a new grid resource allocation method of optimal computational cost using synthetic and real workload traces with respect to other allocation methods; and finally, proposal of some new job scheduling algorithms of optimal performance considering parameters like waiting time, turnaround time, response time, bounded slowdown, completion time and stretch time. The issue is not only to develop new algorithms, but also to evaluate them on an experimental computational grid, using synthetic and real workload traces, along with the other existing job scheduling algorithms. Experimental evaluation confirmed that the proposed grid scheduling algorithms possess a high degree of optimality in performance, efficiency and scalability

Characterization of sorghum germplasm for various morphological and fodder yield parameters

This study was performed to evaluate and characterize 24 sorghum accessions for various morphological and fodder yield parameters. The germplasm displayed considerable variability for leaf color, midrib color, panicle shape, days to 50% flowering, leaf area, flag leaf area, plant height and green fodder yield, while differences of smaller magnitude were observed for number of leaves and tillers plant-1. Genotype Fsd -sorghum was mature early with minimum days to maturity (63) while maximum plant height (232 cm) was observed for Acc.1692. Moreover, Acc.1827 exhibited maximum leaf area (447 cm2) and the highest green fodder yield at 50% maturity (58 t ha-1) was recorded for Acc. 1763. The results of this study indicate that significant genetic diversity exists among the sorghum accessions. The genetic potential of Fsd-sorghum, accessions 1692, 1827 and 1763 can be exploited in future sorghum breeding programs. Further, these genotypes are recommended for commercial cultivation to meet the fodder needs of the country.Keywords: Fodder, Sorghum bicolor, accession

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

Incidence of neurological deficits of post spinal surgery syndrome

Background: Post spinal surgery syndrome (PSSS) is characterized by chronic discomforts post one or more spine operations. Despite advancements in surgical technology, failure rate of back operations has not decreased. These conditions may occur preoperatively, intraoperatively, and postoperatively. Objectives: The primary purpose of this investigation was to ascertain the incidence and causes of neurological complications in patients who have undergone spinal surgery and subsequently developed PSSS. Methods: Cross sectional research was performed at Mardan Medical Complex, Mardan, comprising 82 patients (50 males and 32 females). X-ray studies, MRI, and electromyography was the tool for initial lumbar surgery to confirm the initial diagnosis. Participants were requested to submit the questionnaire and then, their scores were calculated and analyzed as per standard protocols. Results: The potential causes of PSSS, indicated 16 (19.5%) patients with incorrect diagnosis, 24 (29.3%) of the due to surgical technical errors, 10 (12.2%) due to improper pre-operative patient selection and 20 (24.4%) as a result of recurrent disc herniation after surgery. The frequency of cases of complications was spinal fusion (64.09%), followed by kinesiophobia (47.38%), laminectomy (45.98%), depression (40.3%), numbness in lower limbs (36.9%), myelopathy (14.5%) and other neurological deficits (12.56%).&nbsp

In Vitro and In Silico Investigation of Diterpenoid Alkaloids Isolated from Delphinium chitralense

This study reports the isolation of three new C20 diterpenoid alkaloids, Chitralinine A–C (1–3) from the aerial parts of Delphinium chitralense. Their structures were established on the basis of latest spectral techniques and single crystal X-rays crystallographic studies of chitralinine A described basic skeleton of these compounds. All the isolated Compounds (1–3) showed strong, competitive type inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in comparison to standard allanzanthane and galanthamine however, chitralinine-C remained the most potent with IC50 value of 11.64 ± 0.08 μM against AChE, and 24.31 ± 0.33 μM against BChE, respectively. The molecular docking reflected a binding free energy of −16.400 K Cal-mol−1 for chitralinine-C, having strong interactions with active site residues, TYR334, ASP72, SER122, and SER200. The overall findings suggest that these new diterpenoid alkaloids could serve as lead drugs against dementia-related diseases including Alzheimer’s disease

Neuroprotective Potential of Synthetic Mono-Carbonyl Curcumin Analogs Assessed by Molecular Docking Studies

Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their promising in vitro anticholinesterase activities, they were further investigated for in vivo neuroprotective and memory enhancing effects in scopolamine-induced amnesia using elevated plus maze (EPM) and novel object recognition (NOR) behavioral mice models. The effects of the synthesized compounds on the cholinergic system involvement in the brain hippocampus and their binding mode in the active site of cholinesterases were also determined. Compound h2 (p 0.001) and h3 (p 0.001) significantly inhibited the cholinesterases and reversed the effects of scopolamine by significantly reducing TLT (p 0.001) in EPM, while (p 0.001) increased the time exploring the novel object. The % discrimination index (DI) was significantly increased (p 0.001) in the novel object recognition test. The mechanism of cholinesterase inhibition was further validated through molecular docking study using MOE software. The results obtained from the in vitro, in vivo and ex vivo studies showed that the synthesized curcumin analogs exhibited significantly higher memory-enhancing potential, and h3 could be an effective neuroprotective agent. However, more study is suggested to explore its exact mechanism of action

The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% 47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% 32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% 27.9-42.8] and 33.3% 25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study

Background Stratifying risk of postoperative pulmonary complications after major abdominal surgery allows clinicians to modify risk through targeted interventions and enhanced monitoring. In this study, we aimed to identify and validate prognostic models against a new consensus definition of postoperative pulmonary complications. Methods We did a systematic review and international external validation cohort study. The systematic review was done in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched MEDLINE and Embase on March 1, 2020, for articles published in English that reported on risk prediction models for postoperative pulmonary complications following abdominal surgery. External validation of existing models was done within a prospective international cohort study of adult patients (≥18 years) undergoing major abdominal surgery. Data were collected between Jan 1, 2019, and April 30, 2019, in the UK, Ireland, and Australia. Discriminative ability and prognostic accuracy summary statistics were compared between models for the 30-day postoperative pulmonary complication rate as defined by the Standardised Endpoints in Perioperative Medicine Core Outcome Measures in Perioperative and Anaesthetic Care (StEP-COMPAC). Model performance was compared using the area under the receiver operating characteristic curve (AUROCC). Findings In total, we identified 2903 records from our literature search; of which, 2514 (86·6%) unique records were screened, 121 (4·8%) of 2514 full texts were assessed for eligibility, and 29 unique prognostic models were identified. Nine (31·0%) of 29 models had score development reported only, 19 (65·5%) had undergone internal validation, and only four (13·8%) had been externally validated. Data to validate six eligible models were collected in the international external validation cohort study. Data from 11 591 patients were available, with an overall postoperative pulmonary complication rate of 7·8% (n=903). None of the six models showed good discrimination (defined as AUROCC ≥0·70) for identifying postoperative pulmonary complications, with the Assess Respiratory Risk in Surgical Patients in Catalonia score showing the best discrimination (AUROCC 0·700 [95% CI 0·683–0·717]). Interpretation In the pre-COVID-19 pandemic data, variability in the risk of pulmonary complications (StEP-COMPAC definition) following major abdominal surgery was poorly described by existing prognostication tools. To improve surgical safety during the COVID-19 pandemic recovery and beyond, novel risk stratification tools are required. Funding British Journal of Surgery Society